Physiopathogenèse et traitement des maladies du foie (HEPAREG)

Laboratory presentation

The goal of the Physiopathogenesis and Treatment of Liver Diseases Unit is to develop translational research in hepatic pathologies on two major themes: hepatic cancers on the one hand and hepatitis (including viral) on the other hand with the will to propose innovative therapies. It is made up of renowned researchers and clinicians as well as ATRs who make the bridge between the laboratory and the patient's bed. The unit is very involved in international clinical trials for the management of hepatic carcinomas and hepatitis. Furthermore, it benefits from the equipment provided by the Lwoff Institute technical platform and the Hepatinov DHU experts network.

The 20 latest publications

Title Authors Publication date Source
Hepatopulmonary syndrome F. Robert, Laurent Savale 03/01/24 Revue de Medecine Interne
Tight junction proteins and biliary diseases Gregory Merlen, Thierry Tordjmann 03/01/24 Current Opinion in Gastroenterology
Exploring the impact of ursodeoxycholic acid therapy on COVID-19 in a real-word setting Jean Charles Duclos-Vallée 01/01/24 Journal of Medical Virology
Early portal vein thrombosis after hepatectomy for perihilar cholangiocarcinoma: Incidence, risk factors, and management Eric Vibert, Antonio Sa cunha, Daniel Cherqui, Nicolas Golse 12/01/23 Journal of Visceral Surgery
Preneoplastic liver colonization by 11p15.5 altered mosaic cells in young children with hepatoblastoma Catherine Guettier 12/01/23 Nature Communications
Predictors of 6-year event-free survival in Alagille syndrome patients treated with maralixibat, an ileal bile acid transporter inhibitor Emmanuel Gonzales, Emmanuel Jacquemin 12/01/23 Hepatology
Intrinsic cancer cell phosphoinositide 3-kinase δ regulates fibrosis and vascular development in cholangiocarcinoma Vanessa Bou Malham, Nassima Benzoubir, Jean Agnetti, Pei Xuan Song, Didier Samuel, Mylene Sebagh, Ama Gassama-Diagne 12/01/23 Liver International
Immune checkpoints are predominantly co-expressed by clonally expanded CD4<sup>+</sup>FoxP3<sup>+</sup> intratumoral T-cells in primary human cancers Sophie Ferlicot 12/01/23 Journal of Experimental and Clinical Cancer Research
New epidemiologic trends in cholangiocarcinoma Alina Pascale, Olivier Rosmorduc, Jean Charles Duclos-Vallée 11/01/23 Clinics and Research in Hepatology and Gastroenterology
Hepato-pulmonary syndrome A. Sayadi, A. Coilly 11/01/23 Hepato-Gastro and Oncologie Digestive
Cost-effectiveness of screening and valacyclovir-based treatment strategies for first-trimester cytomegalovirus primary infection in pregnant women in France Christelle Vauloup-Fellous 10/01/23 Ultrasound in Obstetrics and Gynecology
Impact of direct antiviral agents for hepatitis C virus -induced liver diseases on registration, waiting list and liver transplant activity in France A. Coilly 10/01/23 Clinics and Research in Hepatology and Gastroenterology
Medical consent in the era of personalized medicine: Issues and recommendations Jean Charles Duclos-Vallée 09/11/23 Medecine/sciences
Liver Histology Before Treatment Withdrawal in Autoimmune Hepatitis: Is It Time to Review the ESPGHAN Recommendations? Emmanuel Jacquemin 09/01/23 Journal of Pediatric Gastroenterology and Nutrition
Congenital Rubella Syndrome Following Rubella Vaccination During Pregnancy Christelle Vauloup-Fellous 09/01/23 Pediatrics
Intensive care management of acute-on-chronic liver failure Eleonora De Martin 08/01/23 Intensive Care Medicine
Hepatic deletion of serine palmitoyl transferase 2 impairs ceramide/sphingomyelin balance, bile acids homeostasis and leads to liver damage in mice Gregory Merlen, I. Doignon, Thierry Tordjmann 08/01/23 Biochimica et Biophysica Acta - Molecular and Cell Biology of Lipids
Transplacental transfer of anti-SARS-CoV-2 neutralizing antibodies in comparison to other pathogens total antibodies Diane Brebant, Sandra Duquesne, Christelle Vauloup-Fellous 08/01/23 Journal of Clinical Virology
Enhanced resonance energy transfer in gold nanoparticles bifunctionalized by tryptophan and riboflavin and its application in fluorescence bioimaging Slavka Kascakova 07/01/23 Colloids and Surfaces B: Biointerfaces
Septin 9 Orients the Apico–Basal Polarity Axis and Controls Plasticity Signals Tingting Cai, Juan Peng, Mohyeddine Omrane, Nassima Benzoubir, Didier Samuel, Ama Gassama-Diagne 07/01/23 Cells

Number of publications of the laboratory by scientific field (2016-2021)

Every paper can be classified in one or more scientific fields. The figure below shows the lab's number of publications in each scientific field, according to the ASJC classification (Elsevier)