Physiopathogenèse et traitement des maladies du foie (HEPAREG)

Présentation du laboratoire

L'unité Physiopathogénèse et traitement des maladies du foie a pour but de développer la recherche translationnelle dans les pathologies hépatiques autour de deux thématiques majeures : les cancers hépatiques d'une part, et les hépatites (dont virales) d'autre part avec la volonté de proposer des thérapies innovantes.
Elle est composée de chercheurs et de cliniciens renommés ainsi que d'ATR qui permettent de faire le pont entre le laboratoire et le lit du malade. L'unité est très impliquée dans les essais cliniques internationaux pour la prise en charge des carcinomes hépatiques et des hépatites. En outre, elle profite des équipements mis à disposition par le plateau technique de l'Institut Lwoff et du réseau d'experts du DHU Hepatinov.

Les 20 dernières publications

Titre Auteurs Date de publication Source
Hepatopulmonary syndrome F. Robert, Laurent Savale 01/03/2024 Revue de Medecine Interne
Tight junction proteins and biliary diseases Gregory Merlen, Thierry Tordjmann 01/03/2024 Current Opinion in Gastroenterology
Exploring the impact of ursodeoxycholic acid therapy on COVID-19 in a real-word setting Jean Charles Duclos-Vallée 01/01/2024 Journal of Medical Virology
Early portal vein thrombosis after hepatectomy for perihilar cholangiocarcinoma: Incidence, risk factors, and management Eric Vibert, Antonio Sa cunha, Daniel Cherqui, Nicolas Golse 01/12/2023 Journal of Visceral Surgery
Preneoplastic liver colonization by 11p15.5 altered mosaic cells in young children with hepatoblastoma Catherine Guettier 01/12/2023 Nature Communications
Predictors of 6-year event-free survival in Alagille syndrome patients treated with maralixibat, an ileal bile acid transporter inhibitor Emmanuel Gonzales, Emmanuel Jacquemin 01/12/2023 Hepatology
Intrinsic cancer cell phosphoinositide 3-kinase δ regulates fibrosis and vascular development in cholangiocarcinoma Vanessa Bou Malham, Nassima Benzoubir, Jean Agnetti, Pei Xuan Song, Didier Samuel, Mylene Sebagh, Ama Gassama-Diagne 01/12/2023 Liver International
Immune checkpoints are predominantly co-expressed by clonally expanded CD4<sup>+</sup>FoxP3<sup>+</sup> intratumoral T-cells in primary human cancers Sophie Ferlicot 01/12/2023 Journal of Experimental and Clinical Cancer Research
New epidemiologic trends in cholangiocarcinoma Alina Pascale, Olivier Rosmorduc, Jean Charles Duclos-Vallée 01/11/2023 Clinics and Research in Hepatology and Gastroenterology
Hepato-pulmonary syndrome A. Sayadi, A. Coilly 01/11/2023 Hepato-Gastro and Oncologie Digestive
Cost-effectiveness of screening and valacyclovir-based treatment strategies for first-trimester cytomegalovirus primary infection in pregnant women in France Christelle Vauloup-Fellous 01/10/2023 Ultrasound in Obstetrics and Gynecology
Impact of direct antiviral agents for hepatitis C virus -induced liver diseases on registration, waiting list and liver transplant activity in France A. Coilly 01/10/2023 Clinics and Research in Hepatology and Gastroenterology
Medical consent in the era of personalized medicine: Issues and recommendations Jean Charles Duclos-Vallée 11/09/2023 Medecine/sciences
Liver Histology Before Treatment Withdrawal in Autoimmune Hepatitis: Is It Time to Review the ESPGHAN Recommendations? Emmanuel Jacquemin 01/09/2023 Journal of Pediatric Gastroenterology and Nutrition
Congenital Rubella Syndrome Following Rubella Vaccination During Pregnancy Christelle Vauloup-Fellous 01/09/2023 Pediatrics
Intensive care management of acute-on-chronic liver failure Eleonora De Martin 01/08/2023 Intensive Care Medicine
Hepatic deletion of serine palmitoyl transferase 2 impairs ceramide/sphingomyelin balance, bile acids homeostasis and leads to liver damage in mice Gregory Merlen, I. Doignon, Thierry Tordjmann 01/08/2023 Biochimica et Biophysica Acta - Molecular and Cell Biology of Lipids
Transplacental transfer of anti-SARS-CoV-2 neutralizing antibodies in comparison to other pathogens total antibodies Diane Brebant, Sandra Duquesne, Christelle Vauloup-Fellous 01/08/2023 Journal of Clinical Virology
Enhanced resonance energy transfer in gold nanoparticles bifunctionalized by tryptophan and riboflavin and its application in fluorescence bioimaging Slavka Kascakova 01/07/2023 Colloids and Surfaces B: Biointerfaces
Septin 9 Orients the Apico–Basal Polarity Axis and Controls Plasticity Signals Tingting Cai, Juan Peng, Mohyeddine Omrane, Nassima Benzoubir, Didier Samuel, Ama Gassama-Diagne 01/07/2023 Cells

Nombre de publications du laboratoire par domaine scientifique (2016-2021)

Chaque publication du laboratoire peut être rangée dans une ou plusieurs disciplines scientifiques : la figure ci-dessus présente le nombre de publications du laboratoire pour chaque discipline de la classification ASJC (Elsevier)