Physiologie et physiopathologie des rétrovirus endogènes et infectieux (RETRO-ENDO)

Laboratory presentation

The team of endogenous retroviruses and retroid elements of the higher eukaryotes works on human infectious and endogenous retroviruses. This laboratory has identified a domain that has immunosuppressive properties that play an essential role in the ability of these viruses to invade their host and in tumorigenesis role. Research also focuses on the ability of tumor cells to escape the antitumor immune response and penetration of the materno-fetal barrier of the mammalian placenta. This research activity, at the junction of virology, oncology, immunology and development, enables new vaccine and therapeutic approaches, taking into account the properties of the identified domains.

The 20 latest publications

Title Authors Publication date Source
mTOR inhibition suppresses salinomycin-induced ferroptosis in breast cancer stem cells by ironing out mitochondrial dysfunctions Sylvie Souquere, Gérard Pierron 11/01/23 Cell Death and Disease
Shell protein composition specified by the lncRNA NEAT1 domains dictates the formation of paraspeckles as distinct membraneless organelles Sylvie Souquere 11/01/23 Nature Cell Biology
FOXO1 Inhibition Generates Potent Nonactivated CAR T Cells against Solid Tumors Mélanie Phayanouvong, Fathia Mami-Chouaib 11/01/23 Cancer immunology research
Performance assessment and validation of a plaque reduction neutralization test (PRNT) in support to yellow fever diagnostic and vaccine clinical trials Anne Dupressoir 04/01/23 Journal of Medical Virology
Caspase Inhibition Modulates Monocyte-Derived Macrophage Polarization in Damaged Tissues Gérard Pierron 02/01/23 International Journal of Molecular Sciences
Therapeutic potential of the human endogenous retroviral envelope protein HEMO: a pan-cancer analysis Amélie Kasperek, Anthony Béguin, Kévin De Azevedo, Thierry Heidmann, Odile Heidmann 04/01/22 Molecular Oncology
Patient-derived organoids identify an apico-basolateral polarity switch associated with survival in colorectal cancer Sylvie Souquere, Gérard Pierron 01/01/22 Journal of Cell Science
Paradoxical implication of BAX/BAK in the persistence of tetraploid cells Gérard Pierron 11/01/21 Cell Death and Disease
Paraspeckles are constructed as block copolymer micelles Gérard Pierron 06/15/21 EMBO Journal
Melanoma Persister Cells Are Tolerant to BRAF/MEK Inhibitors via ACOX1-Mediated Fatty Acid Oxidation Sylvie Souquere, Gérard Pierron 11/24/20 Cell Reports
Comparative analysis of docetaxel: physical and chemical characterisation of Taxotère® and generics Do Bernard, Solgadi Audrey 08/01/20 European Journal of Cancer
Role of the captured retroviral envelope syncytin-B gene in the fusion of osteoclast and giant cell precursors and in bone resorption, analyzed ex vivo and in vivo in syncytin-B knockout mice François Redelsperger, Cécile Vernochet, Thierry Heidmann, Anne Dupressoir 12/01/19 Bone Reports
Dynamic gene regulation by nuclear colony-stimulating factor 1 receptor in human monocytes and macrophages Gérard Pierron, Sylvie Souquere 12/01/19 Nature Communications
RNA is a critical element for the sizing and the composition of phase-separated RNA–protein condensates Sylvie Souquere, Gérard Pierron 12/01/19 Nature Communications
Circulating CASK is associated with recurrent focal segmental glomerulosclerosis after transplantation Francis Harper 07/01/19 PLoS ONE
Lethal Poisoning of Cancer Cells by Respiratory Chain Inhibition plus Dimethyl α-Ketoglutarate Sylvie Souquere, Gérard Pierron 04/16/19 Cell Reports
Identification of the receptor used by the ecotropic mouse GLN endogenous retrovirus Jhen Tsang, David Ribet, Thierry Heidmann, Marie Dewannieux 03/01/19 Journal of Virology
Capture of a Hyena-Specific Retroviral Envelope Gene with Placental Expression Associated in Evolution with the Unique Emergence among Carnivorans of Hemochorial Placentation in Hyaenidae Mathis Funk, Guillaume Cornelis, Cécile Vernochet, Odile Heidmann, Anne Dupressoir, Thierry Heidmann 02/01/19 Journal of Virology
Control of Acute Arboviral Infection by Natural Killer Cells Caroline Petitdemange 02/01/19 Viruses
IFITM proteins inhibit placental syncytiotrophoblast formation and promote fetal demise Anne Dupressoir, Thierry Heidmann 01/01/19 Science

Number of publications of the laboratory by scientific field (2016-2021)

Every paper can be classified in one or more scientific fields. The figure below shows the lab's number of publications in each scientific field, according to the ASJC classification (Elsevier)