Intégrité du génome et cancers (IGC)

Laboratory presentation

The Laboratory Genetic Stability and Oncogenesis works on the cellular and molecular response to DNA alteration. These alterations may be responsible for developmental abnormalities, premature aging, predisposition for the onset of cancer or cell death. The research therefore focuses on understanding the repair mechanisms of human and murine cellular DNA from biochemical, genetic, molecular and cellular analyzes. This work has already led to the creation of numerous innovations protected by 4 patents.

The 20 latest publications

Title Authors Publication date Source
IGH 3'RR recombination uncovers a non-germinal center imprint and c-MYC-dependent IGH rearrangement in unmutated chronic lymphocytic leukemia Said Aoufouchi, Morwenna Le Guillou 02/01/24 Haematologica
Methods for detection of mitochondrial reactive oxygen species in senescent cells Fenniche Salma, Dupuy Corinne 01/01/24 Methods in Cell Biology
Monitoring Chk1 kinase activity dynamics in live single cell imaging assays Olivier Gavet 01/01/24 Methods in Cell Biology
Coordination between human DNA polymerase β and apurinic/apyrimidinic endonuclease 1 in the course of DNA repair Alexander A. Ishchenko, Murat Saparbaev 01/01/24 Biochimie
Hypoxia as a potential inducer of immune tolerance, tumor plasticity and a driver of tumor mutational burden: Impact on cancer immunotherapy Sophie Gad 12/01/23 Seminars in Cancer Biology
Genomic mutation landscape of skin cancers from DNA repair-deficient xeroderma pigmentosum patients P. L. Kannouche, Alain Sarasin 12/01/23 Nature Communications
Immune checkpoints are predominantly co-expressed by clonally expanded CD4<sup>+</sup>FoxP3<sup>+</sup> intratumoral T-cells in primary human cancers Sophie Ferlicot 12/01/23 Journal of Experimental and Clinical Cancer Research
Fanca deficiency is associated with alterations in osteoclastogenesis that are rescued by TNFα Alessia Oppezzo, Lovely Monney, Frédérique Maczkowiak-Chartois, Filippo Rosselli 12/01/23 Cell and Bioscience
Congenital mirror movements are associated with defective polymerisation of RAD51 Pauline Dupaigne 11/01/23 Journal of Medical Genetics
Quercetin improves white adipose tissue redox homeostasis in ovariectomized rats Caroline C. Faria 11/01/23 Journal of Endocrinology
In vivo reduction of RAD51-mediated homologous recombination triggers aging but impairs oncogenesis E. Despras, P. L. Kannouche 10/16/23 EMBO Journal
Epigenomic signature of accelerated ageing in progeroid Cockayne syndrome Alain Sarasin 10/01/23 Aging Cell
FANCA deficiency promotes leukaemic progression by allowing the emergence of cells carrying oncogenic driver mutations Patrycja Pawlikowska, Alessia Oppezzo, Filippo Rosselli 09/08/23 Oncogene
WWOX binds MERIT40 and modulates its function in homologous recombination, implications in breast cancer Josée Guirouilh-Barbat 08/01/23 Cancer Gene Therapy
Trastuzumab deruxtecan in metastatic breast cancer with variable HER2 expression: the phase 2 DAISY trial Vianney Baris, Pierre Laplante, P. L. Kannouche 08/01/23 Nature Medicine
Abasic site-peptide cross-links are blocking lesions repaired by AP endonucleases Alexander A. Ishchenko, Murat Saparbaev 07/07/23 Nucleic Acids Research
Individual Contributions of Amido Acid Residues Tyr122, Ile168, and Asp173 to the Activity and Substrate Specificity of Human DNA Dioxygenase ABH2 Alexander A. Ishchenko, Murat Saparbaev 07/01/23 Cells
A Comparative Analysis of NOX4 Protein Expression in Malignant and Non-Malignant Thyroid Tumors Salma Fenniche, Abir Alghuzlan, Corinne Dupuy 07/01/23 Current Issues in Molecular Biology
Firing of Replication Origins Is Disturbed by a CDK4/6 Inhibitor in a pRb-Independent Manner Su Jung Kim, Michelle Debatisse, Stéphane Koundrioukoff 07/01/23 International Journal of Molecular Sciences
Structural analysis of the Candida albicans mitochondrial DNA maintenance factor Gcf1p reveals a dynamic DNA-bridging mechanism Olivier Piétrement, Joaquim Roca, Eric Le Cam 06/23/23 Nucleic Acids Research

Number of publications of the laboratory by scientific field (2016-2021)

Every paper can be classified in one or more scientific fields. The figure below shows the lab's number of publications in each scientific field, according to the ASJC classification (Elsevier)