Intégrité du génome et cancers (IGC)

Présentation du laboratoire

Le laboratoire Stabilité génétique et oncogenèse travaille sur la réponse cellulaire et moléculaire à l'altération de l'ADN. Ces altérations peuvent être responsables d'anomalies du développement, au vieillissement prématuré, à une prédisposition de l'apparition de cancer ou encore une mort cellulaire. Les recherches portent donc sur la compréhension des mécanismes de réparation de l'ADN de cellulaire humaines et murines à partir d'analyses biochimiques, génétiques, moléculaires et cellulaires. Ces travaux ont déjà permis la création de nombreuses innovations protégées par 4 brevets.

Les 20 dernières publications

Titre Auteurs Date de publication Source
IGH 3'RR recombination uncovers a non-germinal center imprint and c-MYC-dependent IGH rearrangement in unmutated chronic lymphocytic leukemia Said Aoufouchi, Morwenna Le Guillou 01/02/2024 Haematologica
Methods for detection of mitochondrial reactive oxygen species in senescent cells Fenniche Salma, Dupuy Corinne 01/01/2024 Methods in Cell Biology
Monitoring Chk1 kinase activity dynamics in live single cell imaging assays Olivier Gavet 01/01/2024 Methods in Cell Biology
Coordination between human DNA polymerase β and apurinic/apyrimidinic endonuclease 1 in the course of DNA repair Alexander A. Ishchenko, Murat Saparbaev 01/01/2024 Biochimie
Hypoxia as a potential inducer of immune tolerance, tumor plasticity and a driver of tumor mutational burden: Impact on cancer immunotherapy Sophie Gad 01/12/2023 Seminars in Cancer Biology
Genomic mutation landscape of skin cancers from DNA repair-deficient xeroderma pigmentosum patients P. L. Kannouche, Alain Sarasin 01/12/2023 Nature Communications
Immune checkpoints are predominantly co-expressed by clonally expanded CD4<sup>+</sup>FoxP3<sup>+</sup> intratumoral T-cells in primary human cancers Sophie Ferlicot 01/12/2023 Journal of Experimental and Clinical Cancer Research
Fanca deficiency is associated with alterations in osteoclastogenesis that are rescued by TNFα Alessia Oppezzo, Lovely Monney, Frédérique Maczkowiak-Chartois, Filippo Rosselli 01/12/2023 Cell and Bioscience
Congenital mirror movements are associated with defective polymerisation of RAD51 Pauline Dupaigne 01/11/2023 Journal of Medical Genetics
Quercetin improves white adipose tissue redox homeostasis in ovariectomized rats Caroline C. Faria 01/11/2023 Journal of Endocrinology
In vivo reduction of RAD51-mediated homologous recombination triggers aging but impairs oncogenesis E. Despras, P. L. Kannouche 16/10/2023 EMBO Journal
Epigenomic signature of accelerated ageing in progeroid Cockayne syndrome Alain Sarasin 01/10/2023 Aging Cell
FANCA deficiency promotes leukaemic progression by allowing the emergence of cells carrying oncogenic driver mutations Patrycja Pawlikowska, Alessia Oppezzo, Filippo Rosselli 08/09/2023 Oncogene
WWOX binds MERIT40 and modulates its function in homologous recombination, implications in breast cancer Josée Guirouilh-Barbat 01/08/2023 Cancer Gene Therapy
Trastuzumab deruxtecan in metastatic breast cancer with variable HER2 expression: the phase 2 DAISY trial Vianney Baris, Pierre Laplante, P. L. Kannouche 01/08/2023 Nature Medicine
Abasic site-peptide cross-links are blocking lesions repaired by AP endonucleases Alexander A. Ishchenko, Murat Saparbaev 07/07/2023 Nucleic Acids Research
Individual Contributions of Amido Acid Residues Tyr122, Ile168, and Asp173 to the Activity and Substrate Specificity of Human DNA Dioxygenase ABH2 Alexander A. Ishchenko, Murat Saparbaev 01/07/2023 Cells
A Comparative Analysis of NOX4 Protein Expression in Malignant and Non-Malignant Thyroid Tumors Salma Fenniche, Abir Alghuzlan, Corinne Dupuy 01/07/2023 Current Issues in Molecular Biology
Firing of Replication Origins Is Disturbed by a CDK4/6 Inhibitor in a pRb-Independent Manner Su Jung Kim, Michelle Debatisse, Stéphane Koundrioukoff 01/07/2023 International Journal of Molecular Sciences
Structural analysis of the Candida albicans mitochondrial DNA maintenance factor Gcf1p reveals a dynamic DNA-bridging mechanism Olivier Piétrement, Joaquim Roca, Eric Le Cam 23/06/2023 Nucleic Acids Research

Nombre de publications du laboratoire par domaine scientifique (2016-2021)

Chaque publication du laboratoire peut être rangée dans une ou plusieurs disciplines scientifiques : la figure ci-dessus présente le nombre de publications du laboratoire pour chaque discipline de la classification ASJC (Elsevier)