Structure-Activité des Biomolécules Normales et Pathologiques (SABNP)

Laboratory presentation

Based on a multidisciplinary approach, the Structure-Activity Laboratory of Normal and Pathological Biomolecules (SABNP) explore the dynamics and the structure-function relationships of macromolecular assemblies, mainly RNA-protein complexes and microtubules.

The 20 latest publications

Title Authors Publication date Source
RNA and the RNA-binding protein FUS act in concert to prevent TDP-43 spatial segregation Clement Demongin, Vandana Joshi, Léa Ceschi, Bénédicte Desforges, David Pastré, Loic Hamon 03/01/24 Journal of Biological Chemistry
FUS fibrillation occurs through a nucleation-based process below the critical concentration required for liquid-liquid phase separation Emilie Bertrand, Clement Demongin, Ioana Dobra, Juan Carlos Rengifo-Gonzalez, Anastasia S. Singatulina, David Pastré, Loic Hamon 12/01/23 Scientific Reports
FUS RRM regulates poly(ADP-ribose) levels after transcriptional arrest and PARP-1 activation on DNA damage Evgeniya M. Mamontova, Marie Jeanne Clément, Vandana Joshi, Ahmed Bouhss, Juan Carlos Rengifo-Gonzalez, Bénédicte Desforges, Loic Hamon, David Pastré 10/31/23 Cell Reports
UHMK1 is a novel splicing regulatory kinase Serhii Pankivskyi, Jean de Matha Salone, Alexandre Maucuer 04/01/23 Journal of Biological Chemistry
An atlas of substrate specificities for the human serine/threonine kinome Alexandre Maucuer 01/26/23 Nature
Targeting RNA:Protein Interactions with an Integrative Approach Leads to the Identification of Potent YBX1 Inhibitors Krystel El Hage, O. Maciejak, Bénédicte Desforges, Emilie Steiner, Juan Carlos Rengifo-Gonzalez, Hélène Henrie, Marie Jeanne Clément, Vandana Joshi, Ahmed Bouhss, Liya Wang, David Pastré 01/01/23 eLife
Targeting the Major Groove of the Palindromic d(GGCGCC)<inf>2</inf>Sequence by Oligopeptide Derivatives of Anthraquinone Intercalators Krystel El Hage 12/26/22 Journal of Chemical Information and Modeling
PARP1 Activation Controls Stress Granule Assembly after Oxidative Stress and DNA Damage Anastasia S. Singatulina, Bénédicte Desforges, Vandana Joshi, David Pastré 12/01/22 Cells
FUS Microphase Separation: Regulation by Nucleic Acid Polymers and DNA Repair Proteins David Pastré 11/01/22 International Journal of Molecular Sciences
Physico-chemical properties of aluminum adjuvants in vaccines: Implications for toxicological evaluation Ghidaa Badran, Marie Odile David 08/05/22 Vaccine
Structural convergence for tubulin binding of CPAP and vinca domain microtubule inhibitors Patrick A. Curmi 05/10/22 Proceedings of the National Academy of Sciences of the United States of America
A Sub-Micromolar MraY<inf>AA</inf> Inhibitor with an Aminoribosyl Uridine Structure and a (S,S)-Tartaric Diamide: Synthesis, Biological Evaluation and Molecular Modeling Ahmed Bouhss 03/01/22 Molecules
Identification of a small molecule splicing inhibitor targeting UHM domains Asaki Kobayashi, Marie Jeanne Clément, Krystel El Hage, Jean de Matha Salone, David Pastré, Alexandre Maucuer 02/01/22 FEBS Journal
YB-1 Structure/Function Relationship in the Packaging of mRNPs and Consequences for Translation Regulation and Stress Granule Assembly in Cells Loic Hamon, David Pastré 01/01/22 Biochemistry (Moscow)
Meso-substituted cationic 3-and 4-N-Pyridylporphyrins and their Zn(II) derivatives for antibacterial photodynamic therapy Aram G. Gyulkhandanyan 01/01/22 Journal of Innovative Optical Health Sciences
Publisher Correction: Molecular dynamics of the histamine H3 membrane receptor reveals different mechanisms of GPCR signal transduction (Scientific Reports, (2020), 10, 1, (16889), 10.1038/s41598-020-73483-5) Leonardo David Herrera-Zúñiga, José Correa‑Basurto, David Pastré, Patrick A. Curmi, Rachid C. Maroun 12/01/21 Scientific Reports
YB-1 unwinds mRNA secondary structures in vitro and negatively regulates stress granule assembly in HeLa cells Karina Budkina, Krystel El Hage, Marie Jeanne Clément, Bénédicte Desforges, Ahmed Bouhss, Vandana Joshi, Alexandre Maucuer, Loic Hamon, David Pastré 09/27/21 Nucleic Acids Research
The cooperative binding of TDP-43 to GU-rich RNA repeats antagonizes TDP-43 aggregation Juan Carlos Rengifo-Gonzalez, Krystel El Hage, Marie Jeanne Clément, Emilie Steiner, Vandana Joshi, David Pastré, Ahmed Bouhss 09/01/21 eLife
Synthesis, biological evaluation and molecular modeling of urea-containing MraY inhibitors Ahmed Bouhss 07/14/21 Organic and Biomolecular Chemistry
PURE mRNA display and cDNA display provide rapid detection of core epitope motif via high-throughput sequencing Asaki Kobayashi 04/01/21 Biotechnology and Bioengineering

Number of publications of the laboratory by scientific field (2016-2021)

Every paper can be classified in one or more scientific fields. The figure below shows the lab's number of publications in each scientific field, according to the ASJC classification (Elsevier)