Signalisation, radiobiologie et cancer (SRC)

Laboratory presentation

The ETIC unit is responsible for major discoveries in the field of developmental biology, particularly in the neural crest and melanocyte lineage, as well as in the pathophysiology of melanoma and retinoblastoma. It works to elucidate the cellular and molecular mechanisms of normal and tumor development of melanocytes with the dual objective of identifying therapeutic targets and leading to new treatments in melanomas associated or not with radiotherapies. In collaboration with clinicians at the Curie Institute, teams can work with samples of patients with melanoma. They also benefit from the numerous technical platforms of the Institut Curie as well as the Protontherapy site on the Orsay campus.

The 20 latest publications

Title Authors Publication date Source
Loss of Dicer in Newborn Melanocytes Leads to Premature Hair Graying and Changes in Integrin Expression Juliette U. Bertrand, Valérie Petit, Zackie Aktary, Pierre Sohier, Véronique Delmas, Lionel Larue 03/01/24 Journal of Investigative Dermatology
LEF-1 immunohistochemistry, a better diagnostic biomarker than b-catenin for medulloblastoma, WNT-activated subtyping Olivier Ayrault 02/01/24 Journal of Neuropathology and Experimental Neurology
Caffeic Acid Phenethyl Ester (CAPE), a natural polyphenol to increase the therapeutic window for lung adenocarcinomas M. Dubail, C. Fouillade 01/01/24 Radiotherapy and Oncology
miniSCIDOM: a scintillator-based tomograph for volumetric dose reconstruction of single laser-driven proton bunches A. Corvino 01/01/24 High Power Laser Science and Engineering
mTert induction in p21-positive cells counteracts capillary rarefaction and pulmonary emphysema C. Fouillade 01/01/24 EMBO Reports
An interactive murine single-cell atlas of the lung responses to radiation injury Sandra Curras-Alonso, Juliette Soulier, Sophie Heinrich, Hugo Laporte, Marie Dutreix, Vincent Favaudon, A. Londoño-Vallejo, C. Fouillade 12/01/23 Nature Communications
Imaging and multi-omics datasets converge to define different neural progenitor origins for ATRT-SHH subgroups Celio Pouponnot, Olivier Ayrault 12/01/23 Nature Communications
Clinical outcome of pediatric medulloblastoma patients with Li-Fraumeni syndrome Olivier Ayrault, Jacob Torrejon 12/01/23 Neuro-Oncology
Lung Organotypic Slices Enable Rapid Quantification of Acute Radiotherapy Induced Toxicity M. Dubail, Sophie Heinrich, Lucie Portier, Jessica Bastian, Lilia Aggar, Nathalie Berthault, A. Londoño-Vallejo, Marie Dutreix, C. Fouillade 10/01/23 Cells
Multi-omics comparison of malignant and normal uveal melanocytes reveals molecular features of uveal melanoma Géraldine Liot, Simon Saule 09/26/23 Cell Reports
RadioTransNet, Radiotherapy Translational and Preclinical Research Network: Results from the dedicated French cancer institute (INCa) call for projects Yolanda Prezado 09/01/23 Cancer/Radiotherapie
ASO Visual Abstract: New Robotic System with Wristed Micro-Instruments Allows Precise Reconstructive Microsurgery Alberto Ballestín 09/01/23 Annals of Surgical Oncology
Calcineurin-Dependent Homeostatic Response of C. elegans Muscle Cells upon Prolonged Activation of Acetylcholine Receptors Benjamin Bonneau 09/01/23 Cells
Monte Carlo study of the free radical yields in minibeam radiation therapy Thongchai A.M. Masilela, Yolanda Prezado 08/01/23 Medical Physics
Proton FLASH Radiation Therapy and Immune Infiltration: Evaluation in an Orthotopic Glioma Rat Model Lorea Iturri, Annaïg Bertho, Marjorie Juchaux, Cristèle Gilbert, Julie Espenon, Yolanda Prezado 07/01/23 International Journal of Radiation Oncology Biology Physics
Double scattering and pencil beam scanning Monte Carlo workflows for proton therapy retrospective studies on radiation-induced toxicities A. M.M. Leite 06/01/23 Cancer/Radiotherapie
Two induced pluripotent stem cell (iPSC) lines derived from patients affected by Waardenburg syndrome type 1 retain potential to activate neural crest markers Mansour Alkobtawi, Patrick Pla, Subham Seal, Anne H. Monsoro-Burq 06/01/23 Stem Cell Research
LEIBNIZ’ MILITARY CONCEPTION OF SOVEREIGNTY Laurynas Adomaitis 05/01/23 History of Political Thought
Molecular characterisation defines clinically-actionable heterogeneity within Group 4 medulloblastoma and improves disease risk-stratification Olivier Ayrault 05/01/23 Acta Neuropathologica
Class I HDAC inhibitor entinostat synergizes with PLK1 inhibitors in MYC-amplified medulloblastoma cells Julie Talbot, Flavia Bernardi, Olivier Ayrault 05/01/23 Journal of Neuro-Oncology

Number of publications of the laboratory by scientific field (2016-2021)

Every paper can be classified in one or more scientific fields. The figure below shows the lab's number of publications in each scientific field, according to the ASJC classification (Elsevier)