Lipides : systèmes analytiques et biologiques (Lip(Sys)²)

Laboratory presentation

The Lip(Sys)² is a research unit at the interface between biology, analytical chemistry and biochemistry that seeks to dissect the mechanisms of lipid homeostasis, in particular as regards lipids membranaires with applications in the fields of the atherosclerosis, the dermatology and the cosmetic. It also participates in anthropological projects in which it analyzes lipids from waxes, balms or ointments used by past civilizations. The unit is subdivided into three distinct groups: the atherosclerosis: homeostasis and trafficking of macrophages cholesterol team, the pharmaceutical analytical chemistry team and the LETIAM. Located on the site of the faculty of pharmacy, it benefits from the accessibility and expertise of the technical platforms of IPSIT. Its close connection with the European Hospital George Pompidou ensures a highly competitive translational research.

The 20 latest publications

Title Authors Publication date Source
Comprehensive analysis of oxylipins using reverse phase liquid chromatography and data dependent acquisition workflow on LTQ-Orbitrap® Velos Pro Kodjo Nouwade, Sana Tfaili, Hani Dakroub, Danielle Libong, Jean Louis Paul, Natalie Fournier, Pierre Chaminade 01/01/24 Talanta
Hydration for Adult Patients with Nephrolithiasis: Specificities and Current Recommendations Simon Travers 12/01/23 Nutrients
Strat-M® positioning for skin permeation studies: A comparative study including EpiSkin® RHE, and human skin Joudi Bakar, Rime Michael-Jubeli, Ali Tfayli 11/25/23 International Journal of Pharmaceutics
Effects of solar radiations on stratum corneum hydration: Part I, protective role of skin surface lipids Ali Assi, Rime Michael-Jubeli, Arlette Baillet-Guffroy, Ali Tfayli 08/01/23 Journal of Biophotonics
Targeting mitochondrial function in macrophages: A novel treatment strategy for atherosclerotic cardiovascular disease? Pierre Hadrien Becker, P. Thérond, Pauline Gaignard 07/01/23 Pharmacology and Therapeutics
In vitro Raman imaging of human macrophages: Impact of eicosapentaenoic acid on the hydrolysis of cholesterol esters in lipid droplets A. Muhieddine, Natalie Fournier, Hani Dakroub, Ali Assi, Jean Louis Paul, Ali Tfayli, Pierre Chaminade, Sana Tfaili 05/01/23 Talanta
Bioinspired Synthesis of Pulvinic Acids Including Xerocomic Acid and Fluorescence Properties of Bis-lactone Intermediates Martin Souce, Athéna Kasselouri 02/17/23 European Journal of Organic Chemistry
Glycerol and natural sugar-derived complex modulate differentially stratum corneum water-binding properties and structural parameters in an in vitro Raman-desorption model Ali Tfayli 01/01/23 Journal of Biophotonics
Photosensitizers incorporation in SOPC films at different hydration levels Martin Souce, Ali Tfayli, Athéna Kasselouri 01/01/23 Biochimica et Biophysica Acta - Biomembranes
New Cocrystallization Method: Non-photochemical Laser-Induced Nucleation of a Cocrystal of Caffeine-Gallic Acid in Water Ali Assi, Ali Tfayli 10/05/22 Crystal Growth & Design
Pharmacokinetics, biodistribution, and activity of Amphotericin B-loaded nanocochleates on the Leishmania donovani murine visceral leishmaniasis model Natalie Fournier 08/25/22 International Journal of Pharmaceutics
Estimating the Analytical Performance of Raman Spectroscopy for Quantification of Active Ingredients in Human Stratum Corneum Ali Tfayli 05/01/22 Molecules
Discriminative and quantitative analysis of norepinephrine and epinephrine by surface-enhanced Raman spectroscopy with gold nanoparticle suspensions Antoine Dowek, Marion Berge, Patrice Prognon, Ali Tfayli, Laetitia Minh Maï Le, Eric Caudron 01/01/22 Analytical and Bioanalytical Chemistry
Towards harmonization of solutions used for cystic fibrosis diagnosis by nasal potential difference measurements: A formulation approach with CHESS® software Eric Caudron, Patrice Prognon 01/01/22 Annales Pharmaceutiques Francaises
The linoleic acid content of the stratum corneum of ichthyotic golden retriever dogs is reduced as compared to healthy dogs and a significant part is oxidized in both free and esterified forms A. Solgadi 12/01/21 Metabolites
Investigation of stationary phases performance for eicosanoids profiling in RP-HPLC Kodjo Nouwade, Sana Tfaili, Pierre Chaminade 11/01/21 Analytical and Bioanalytical Chemistry
Eicosapentaenoic acid membrane incorporation stimulates ABCA1-mediated cholesterol efflux from human THP-1 macrophages Benoît Noël 11/01/21 Biochimica et Biophysica Acta - Molecular and Cell Biology of Lipids
Rapid assessment of triacylglycerol fatty acyls composition by LC-APPI<sup>+</sup>-HRMS using monoacylglycerol like fragments intensities A. Solgadi 09/15/21 Analytica Chimica Acta
Raman confocal microscopy and biophysics multiparametric characterization of the skin barrier evolution with age Aline Rigal, Rime Michael-Jubeli, Arlette Baillet-Guffroy, Ali Tfayli 09/01/21 Journal of Biophotonics
Prenatal air pollution exposure to diesel exhaust induces cardiometabolic disorders in adulthood in a sex-specific manner Natalie Fournier 09/01/21 Environmental Research

Number of publications of the laboratory by scientific field (2016-2021)

Every paper can be classified in one or more scientific fields. The figure below shows the lab's number of publications in each scientific field, according to the ASJC classification (Elsevier)