Laboratoire Européen de Recherche pour la Polyarthrite rhumatoïde (GENHOTEL)

Laboratory presentation

GenHotel's goal is to clarify the multifactorial determinism of rheumatoid arthritis. In this context, research activities focus on characterization of sequencing, structural and expression variants from genomic data of patients and their families. Interaction between risk factors is also investigated.

We also develop a computational systems biology approach with the reconstruction of a disease-specific interaction network by integrating small scale and multi-omic data, and the automatic inference of a large scale boolean model in order to perform dynamical studies and in silico simulations.

The final purpose is to contribute to new drug target development, with a view to prevent and cure this disease. The research methodology will be extended to other diseases having a major impact on public health, through national and international collaborations.