Intégrité du Génome, ARN et Cancer (GIRC)

Laboratory presentation

The GSC laboratory studies the genetic and genotoxic events that occur in the development of cancers. The work is shared among 8 teams working in synergy on DNA replication, its repair, recombination phenomena, RNA and miRNA regulation, oxidative stress and radiation response.
Integrated in the Orsay Research Center, the GSC benefits from an integrated imaging platform and the numerous technical platforms of the Institut Curie (SGA, experimental radiotherapy, high-throughput DNA sequencing, etc.).

The 20 latest publications

Title Authors Publication date Source
Disordered regions and folded modules in CAF-1 promote histone deposition in Schizosaccharomyces pombe Fouad Ouasti, Maxime Audin, Mehdi Tachekort, Elizabeth Cesard, Virginie Ropars, Paloma Fernández Varela, Gwenaelle Moal, Jessica Andreani, Raphaël Guerois, Francoise Ochsenbein 02/20/24 eLife
MAP9/MAPH-9 supports axonemal microtubule doublets and modulates motor movement Mariya Genova, Maria M. Magiera, Carsten Janke 01/22/24 Developmental Cell
BRCA1/2 Haploinsufficiency: Exploring the Impact of Losing one Allele Anna Minello, Aura Carreira 01/01/24 Journal of Molecular Biology
Choroid plexuses carry nodal-like cilia that undergo axoneme regression from early adult stage Carsten Janke, Maria M. Magiera 12/04/23 Developmental Cell
Replication gap suppression depends on the double-strand DNA binding activity of BRCA2 Domagoj Vugic, Isaac Dumoulin, Charlotte Martin, Anna Minello, Rady Chaaban, Catharina von Nicolai, Virginie Boucherit, Aura Carreira 12/01/23 Nature Communications
An interactive murine single-cell atlas of the lung responses to radiation injury Sandra Curras-Alonso, Juliette Soulier, Sophie Heinrich, Hugo Laporte, Marie Dutreix, Vincent Favaudon, A. Londoño-Vallejo, C. Fouillade 12/01/23 Nature Communications
Harnessing the MYB-dependent TAL1 5’super-enhancer for targeted therapy in T-ALL Christine Tran-Quang, Jacques Ghysdael 12/01/23 Molecular Cancer
53BP1 interacts with the RNA primer from Okazaki fragments to support their processing during unperturbed DNA replication Didier Busso, Xavier Veaute, Pascale Bertrand 11/28/23 Cell Reports
Revised fission yeast gene and allele nomenclature guidelines for machine readability Sarah Lambert 11/01/23 Genetics
The multifaceted functions of homologous recombination in dealing with replication-associated DNA damages Shrena Chakraborty, Kamila Schirmeisen, Sarah Lambert 09/01/23 DNA Repair
Tubulin engineering by semi-synthesis reveals that polyglutamylation directs detyrosination Carsten Janke 08/01/23 Nature Chemistry
Post-transcriptional checkpoints in autoimmunity Stéphan Vagner 08/01/23 Nature Reviews Rheumatology
Editorial for the ‘Reciprocal Links between RNA Metabolism and DNA Damage’ Special Issue: July 2023 Martin Dutertre 08/01/23 Genes
A bi-steric mTORC1-selective inhibitor overcomes drug resistance in breast cancer Albertas Navickas 07/07/23 Oncogene
An mRNA processing pathway suppresses metastasis by governing translational control from the nucleus Albertas Navickas 06/01/23 Nature Cell Biology
RNA:DNA hybrids from Okazaki fragments contribute to establish the Ku-mediated barrier to replication-fork degradation Charlotte Audoynaud, Kamila Schirmeisen, Anissia Ait Saada, Virginie Boucherit, Anusha Chaudhuri, Karine Fréon, Sarah Lambert 04/06/23 Molecular Cell
Post-transcriptional polyadenylation site cleavage maintains 3′-end processing upon DNA damage Rym Sfaxi, Biswendu Biswas, Galina Boldina, Mandy Cadix, Martin Dutertre, Stéphan Vagner 04/03/23 EMBO Journal
The tubulin code in mammalian sperm development and function Sudarshan Gadadhar, Carsten Janke 03/15/23 Seminars in Cell and Developmental Biology
Microtubule and auditory function – an underestimated connection Carsten Janke 03/15/23 Seminars in Cell and Developmental Biology
The tubulin code: Empowering microtubules Maria M. Magiera 03/15/23 Seminars in Cell and Developmental Biology

Number of publications of the laboratory by scientific field (2016-2021)

Every paper can be classified in one or more scientific fields. The figure below shows the lab's number of publications in each scientific field, according to the ASJC classification (Elsevier)