Institut de Chimie des Substances Naturelles (ICSN)

Laboratory presentation

With a staff of nearly 200 people, ICSN is the chemistry center of the CNRS campus of Gif-sur-Yvette. The Institute is located on the edge of the future Paris-Saclay campus, which will bring together nearly 10% of French research, and is an integral part of this new University. The ICSN develops activities at the chemistry-biology interface, with natural substances as object of study and main source of inspiration.
Organized in four departments, it has multidisciplinary expertise in organic exploratory chemistry, medicinal chemistry and natural substances, biological chemistry, and structural and analytical biology and chemistry. It relies on state-of-the-art equipment and researchers and engineers with unique know-how.
Internationally, it coordinates numerous national and European research projects. At the origin of many valued patents and startups, the ICSN regularly collaborates with small and large companies in the pharmaceutical and agro-food fields.

The 20 latest publications

Title Authors Publication date Source
Novel supramolecular co-crystal of 8-hydroxyquinoline with acetone-(2,4-dinitrophenyl)hydrazone: One pot synthesis, structural characterization, Hirshfeld surface and energy framework analysis, computational investigation and molecular docking study Pascal Retailleau 03/15/24 Journal of Molecular Structure
Catalyst-Controlled Intermolecular Homobenzylic C(sp<sup>3</sup>)-H Amination for the Synthesis of β-Arylethylamines Erwan Brunard, Vincent Boquet, Tanguy Saget, Philippe Dauban 03/06/24 Journal of the American Chemical Society
Erythrocarpines I–N, new limonoids from the barks of Chisocheton erythrocarpus and their neuroprotective effects against hydrogen peroxide in NG108–15 cells Marc Litaudon 03/01/24 Fitoterapia
Five undescribed aryltetralin lignans with cytotoxic activities from the fruits of Cleistanthus eberhardtii Marc Litaudon 03/01/24 Fitoterapia
Biochemical and cellular characterization of the CISD3 protein: Molecular bases of cluster release and destabilizing effects of nitric oxide Michel Lepoivre, Cindy Vallières, M. P. Golinelli-Cohen 03/01/24 Journal of Biological Chemistry
Successive β-Glycosylations of Tiacumicinone: Formal Total Synthesis of Tiacumicin B and Access to a d-Mannoside Analog Estelle Messe, Vincent Servajean, Caroline Rubéru, Jean François Gallard, Vincent Steinmetz, Stéphanie Norsikian 02/19/24 European Journal of Organic Chemistry
Development of nanoparticles based on amphiphilic cyclodextrins for the delivery of active substances Christina Sizun 02/15/24 International Journal of Pharmaceutics
Mo-catalyzed cyclization of N-vinylindoles and skatoles: synthesis of dihydroindolo[1,2-c]-quinazolines and dihydroindolo[3,2-b]-indoles, and evaluation of their anticancer activities Pascal Retailleau 02/08/24 Organic Chemistry Frontiers
EGCG-like non-competitive inhibitor of DYRK1A rescues cognitive defect in a down syndrome model Marco Antônio G.B. Gomes, Nicolas George, Nadia Fleary-Roberts, Robert H. Dodd, Kevin Cariou 02/05/24 European Journal of Medicinal Chemistry
Sulfur- and Amine- Promoted Multielectron Autoredox Transformation of Nitromethane: Multicomponent Access to Thiourea Derivatives Supasorn Phaenok, Pascal Retailleau, Thanh Binh Nguyen 02/01/24 Chemistry - A European Journal
Crystal structure of poly[hexa-μ-bromido-bis{2-[1-(pyridin-2-yl)ethylideneamino]ethanolato}tetracopper(II)] Pascal Retailleau 02/01/24 Acta Crystallographica Section E: Crystallographic Communications
Visualization of an Endogenous Mitochondrial Azoreductase Activity under Normoxic Conditions Using a Naphthalimide Azo-Based Fluorogenic Probe Laurane Michel, Laurie Askenatzis, Marie Ange Badet-Denisot, Jerome Bignon, Philippe Durand, Arnaud Chevalier 01/30/24 Analytical Chemistry
Combination of Machine Learning and Empirical Computation for the Structural Validation of Trirosaline, a Natural Trimeric Monoterpene Indole Alkaloid from Catharanthus roseus Jean François Gallard 01/12/24 Organic Letters
Sodium sulfide-promoted regiodefined redox condensation of o-nitroanilines with aryl ketones to benzo[a]phenazines and quinoxalines Pascal Retailleau, Thanh Binh Nguyen 01/10/24 Organic and Biomolecular Chemistry
Spatialized Metabolomic Annotation Combining MALDI Imaging and Molecular Networks Marceau Levasseur, Nicolas Elie, Véronique Eparvier, David Touboul 01/09/24 Analytical Chemistry
Multiscale organisation of lead carboxylates in artistic oil binders Frédéric Gobeaux 01/04/24 Physical Chemistry Chemical Physics
Structural, stability and relaxation features of lanthanide-complexes designed for multimodal imaging detection of enzyme activities Rémy Jouclas, Pascal Retailleau, Vincent Steinmetz, Philippe Durand 01/01/24 European Journal of Inorganic Chemistry
Base-Catalyzed Synthesis of N-Aryl Thioacetamides from Multicomponent Reaction of Phenylacetylenes, Sulfur and Anilines Thanh Binh Nguyen 01/01/24 European Journal of Organic Chemistry
Pseudomonas aeruginosa antimicrobial susceptibility profiles, resistance mechanisms and international clonal lineages: update from ESGARS-ESCMID/ISARPAE Group Bogdan I. Iorga 01/01/24 Clinical Microbiology and Infection
Baldwin and Whitehead’s Manzamine Alkaloids Biosynthesis Hypothesis Involves a Finely Tuned Reactivity of Acrolein: Automated Extraction of Reactivity Patterns from LC-MS<sup>2</sup> Data Jean François Gallard 01/01/24 Organic Letters

Number of publications of the laboratory by scientific field (2016-2021)

Every paper can be classified in one or more scientific fields. The figure below shows the lab's number of publications in each scientific field, according to the ASJC classification (Elsevier)