Ingénierie et Plateformes au Service de l'Innovation Thérapeutique (IPSIT)

Laboratory presentation

L’Institut Paris Saclay d’Innovation Thérapeutique (IPSIT) is a mixed unit of service (UMS) composed of 11 technological platforms. It plays a leading role in the development of the scientific projects of the associated units of Châtenay-Malabry, Clamart and Plessis Robinson sites whose common objectives are to identify new therapeutic targets. IPSIT is also at the service of private and public research laboratories from the Île-de-France Sud region.

The 20 latest publications

Title Authors Publication date Source
Corrigendum to “Transcriptome profiling of the fungus Aspergillus nidulans exposed to a commercial glyphosate-based herbicide under conditions of apparent herbicide tolerance” [Environ. Res. (2020) 182:109116] (Environmental Research (2020) 182, (S0013935120300074), (10.1016/j.envres.2020.109116)) Valérie Nicolas, Céline Boursier 11/01/23 Environmental Research
Hacd2 deficiency in mice leads to an early and lethal mitochondrial disease Bastien Prost, A. Solgadi 03/01/23 Molecular Metabolism
Influence of Hydrophobic Groups Attached to Amphipathic Polymers on the Solubilization of Membrane Proteins along with Their Lipids Bastien Prost, A. Solgadi 10/18/22 Analytical Chemistry
P2X7 purinergic receptor plays a critical role in maintaining T-cell homeostasis and preventing lupus pathogenesis Amine Mellouk, Tom Hutteau-Hamel, Hanaa Safya, Françoise Mercier-Nomé, Pierre Bobé 09/29/22 Frontiers in Immunology
Unequal Behaviour between Hydrolysable Functions of Nirmatrelvir under Stress Conditions: Structural and Theoretical Approaches in Support of Preformulation Studies Bastien Prost 08/01/22 Pharmaceutics
Rapid assessment of fatty acyls chains of phospholipids and plasmalogens by atmospheric pressure chemical ionization in positive mode and high-resolution mass spectrometry using in-source generated monoacylglycerol like fragments intensities A. Solgadi, Bastien Prost 06/21/22 Journal of Chromatography A
Hippocampal Excitatory Synaptic Transmission and Plasticity Are Differentially Altered during Postnatal Development by Loss of the X-Linked Intellectual Disability Protein Oligophrenin-1 Florent Dumont 05/01/22 Cells
Transcriptional profiling of β-2M<sup>−</sup>SPα-6<sup>+</sup>THY1<sup>+</sup> spermatogonial stem cells in human spermatogenesis Florent Dumont 04/12/22 Stem Cell Reports
Before in vivo studies: In vitro screening of sphingomyelin nanosystems using a relevant 3D multicellular pancreatic tumor spheroid model Valérie Nicolas, Severine Domenichini 04/05/22 International Journal of Pharmaceutics
Modulation of the Bile Acid Enterohepatic Cycle by Intestinal Microbiota Alleviates Alcohol Liver Disease Dragos Ciocan, Madeleine Spatz, Nicolas Trainel, Kévin Hardonnière, Cindy Hugot, G. Perlemuter, Anne Marie Cassard 03/01/22 Cells
The unforeseen intracellular lifestyle of Enterococcus faecalis in hepatocytes Nicolas Trainel, Anne Marie Cassard 01/01/22 Gut Microbes
Abnormal migration behavior linked to Rac1 signaling contributes to primordial germ cell exhaustion in Fanconi anemia pathway-deficient Fancg-/- embryos Florent Dumont 01/01/22 Human Molecular Genetics
Spatiotemporal AMPKα2 deletion in mice induces cardiac dysfunction, fibrosis and cardiolipin remodeling associated with mitochondrial dysfunction in males only A. Solgadi 12/01/21 Biology of Sex Differences
The linoleic acid content of the stratum corneum of ichthyotic golden retriever dogs is reduced as compared to healthy dogs and a significant part is oxidized in both free and esterified forms A. Solgadi 12/01/21 Metabolites
Anticancer properties of indole derivatives as IsoCombretastatin A-4 analogues Bastien Prost 11/05/21 European Journal of Medicinal Chemistry
Kcnk3 dysfunction exaggerates the development of pulmonary hypertension induced by left ventricular pressure overload Valérie Domergue 11/01/21 Cardiovascular Research
Multi-tissue characterization of GILZ expression in dendritic cell subsets at steady state and in inflammatory contexts Françoise Mercier-Nomé 11/01/21 Cells
Gut microbiota reshaped by pectin treatment improves liver steatosis in obese mice Françoise Mercier-Nomé 11/01/21 Nutrients
Rapid assessment of triacylglycerol fatty acyls composition by LC-APPI<sup>+</sup>-HRMS using monoacylglycerol like fragments intensities A. Solgadi 09/15/21 Analytica Chimica Acta
Tuning morphology of Pickering emulsions stabilised by biodegradable PLGA nanoparticles: How PLGA characteristics influence emulsion properties Valérie Nicolas 08/01/21 Journal of Colloid and Interface Science

Number of publications of the laboratory by scientific field (2016-2021)

Every paper can be classified in one or more scientific fields. The figure below shows the lab's number of publications in each scientific field, according to the ASJC classification (Elsevier)