Immunologie intégrative des tumeurs et immunothérapie des cancers (INTIM)

Laboratory presentation

The laboratory Tumor Integrative Immunology is studying tumor antigens, T-cell reactivity, the impact of the tumor microenvironment on tumor resistance (role on plasticity in particular) and more generally genetics and biology of breast cancer, lung, kidneys and cancers related to melanomas. This work are undertaken thanks to partnerships with industrial companies, which has allowed 2 patents filing as well as the creation of 2 startups and the development of new innovative immunotherapy approaches.

The 20 latest publications

Title Authors Publication date Source
Amphiregulin from regulatory T cells promotes liver fibrosis and insulin resistance in non-alcoholic steatohepatitis Julien Adam 02/13/24 Immunity
Sunitinib Treatment of VHL C162F Cells Slows Down Proliferation and Healing Ability via Downregulation of ZHX2 and Confers a Mesenchymal Phenotype Stéphanie Buart, Isabelle Damei, Salem Chouaib 01/01/24 Cancers
Hypoxia as a potential inducer of immune tolerance, tumor plasticity and a driver of tumor mutational burden: Impact on cancer immunotherapy Sophie Gad 12/01/23 Seminars in Cancer Biology
Glomerular Filtration Rate Measured Based on Iomeprol Clearance Assessed at CT Urography in Living Kidney Donor Candidates Antoine Durrbach 12/01/23 Radiology
FOXO1 Inhibition Generates Potent Nonactivated CAR T Cells against Solid Tumors Mélanie Phayanouvong, Fathia Mami-Chouaib 11/01/23 Cancer immunology research
The search for therapeutic targets in lung cancer: Preclinical and human studies of carcinoembryonic antigen-related cell adhesion molecule 5 expression and its associated molecular landscape Julien Adam 10/01/23 Lung Cancer
Multicenter Harmonization Study of Pan-Trk Immunohistochemistry for the Detection of NTRK3 Fusions Julien Adam 08/01/23 Modern Pathology
Genomic Instability and Protumoral Inflammation Are Associated with Primary Resistance to Anti-PD-1 + Antiangiogenesis in Malignant Pleural Mesothelioma Julien Adam 04/01/23 Cancer Discovery
Nonskeletal and skeletal effects of high doses versus low doses of vitamin D<inf>3</inf> in renal transplant recipients: Results of the VITALE (VITamin D supplementation in renAL transplant recipients) study, a randomized clinical trial Antoine Durrbach 03/01/23 American Journal of Transplantation
Progressive Multifocal Leukoencephalopathy Treated by Immune Checkpoint Inhibitors Jacques Gasnault 02/01/23 Annals of Neurology
Hypoxia, a Targetable Culprit to Counter Pancreatic Cancer Resistance to Therapy Salem Chouaib 02/01/23 Cancers
The roles of different forms of IL-15 in human melanoma progression Salem Chouaib, Stéphanie Buart 01/01/23 Frontiers in Immunology
Tumor-resident memory T cells as a biomarker of the response to cancer immunotherapy Isabelle Damei, Tatiana Trickovic, Fathia Mami-Chouaib, Stéphanie Corgnac 01/01/23 Frontiers in Immunology
State-of-the-art therapeutic strategies for targeting cancer stem cells in prostate cancer Salem Chouaib 01/01/23 Frontiers in Oncology
Tumor microenvironment-induced tumor cell plasticity: relationship with hypoxic stress and impact on tumor resistance Salem Chouaib 01/01/23 Frontiers in Oncology
FAM3C in circulating tumor-derived extracellular vesicles promotes non-small cell lung cancer growth in secondary sites Jean Paul Thiery 01/01/23 Theranostics
Jejunum-derived NF-κB reporter organoids as 3D models for the study of TNF-alpha-induced inflammation Flora Doffe 12/01/22 Scientific Reports
Safety, recommended dose, efficacy and immune correlates for nintedanib in combination with pembrolizumab in patients with advanced cancers Laetitia Grynszpan, Julien Adam 12/01/22 Journal of Experimental and Clinical Cancer Research
Editorial: The intricate innate immune-cancer cell relationship in the context of tumor angiogenesis, immunity and microbiota: The angiogenic switch in the tumor microenvironment as a key target for immunotherapies Salem Chouaib 10/06/22 Frontiers in Immunology
Designing Organoid Models to Monitor Cancer Progression, Plasticity and Resistance: The Right Set Up for the Right Question Flora Doffe, Stéphane Terry, Salem Chouaib, Pierre Savagner 08/01/22 Cancers

Number of publications of the laboratory by scientific field (2016-2021)

Every paper can be classified in one or more scientific fields. The figure below shows the lab's number of publications in each scientific field, according to the ASJC classification (Elsevier)