Immunologie anti-tumorale et immunothérapie des cancers (ITIC)

Laboratory presentation

The laboratory of cancer immunology and immunotherapy against cancer has 2 major research themes. The first is the immunology of tumors and immunotherapy against cancer and the second is the role of mRNA translation in the antigen presentation. These topics include studies on the intestinal microbiota and tumors inflammation, immunotherapy customized by monoclonal antibodies or on the cross-presentation to MHC class I on antigenic peptides. This research focuses on a better understanding of immunology in cancer patients and to improve personalized treatments to better fight this disease. This work in partnership with numerous industrial partners has already enabled the implementation of 6 patents.

The 20 latest publications

Title Authors Publication date Source
A new step in understanding mouse cDC ontogeny Charles Antoine Dutertre 03/01/24 Nature Immunology
Thermal Ablation Combined with Immune Checkpoint Blockers: A 10-Year Monocentric Experience Aurélien Marabelle, Lambros Tselikas 03/01/24 Cancers
Phase I/II Study of the WEE1 Inhibitor Adavosertib (AZD1775) in Combination with Carboplatin in Children with Advanced Malignancies: Arm C of the AcSé-ESMART Trial Anne C. Harttrampf, Windy Rondof, Souad Nebchi, Birgit Geoerger 02/15/24 Clinical Cancer Research
Fate mapping of Spp1 expression reveals age-dependent plasticity of disease-associated microglia-like cells after brain injury Florent Ginhoux 02/13/24 Immunity
METRO-PD1: Phase 1 study of nivolumab in combination with metronomic chemotherapy in children and adolescents with relapsing/refractory solid tumors Birgit Geoerger 02/01/24 European Journal of Cancer
Correction: Metabolomic analyses of COVID-19 patients unravel stage-dependent and prognostic biomarkers (Cell Death & Disease, (2021), 12, 3, (258), 10.1038/s41419-021-03540-y) François Xavier Danlos, Jean Eudes Fahrner, Anne Goubet, Agathe Dubuisson, Lisa Derosa, Delphine Bredel, Séverine Mouraud, Laurence Zitvogel, Aurélien Marabelle 02/01/24 Cell Death and Disease
Melanoma and microbiota: Current understanding and future directions Lisa Derosa, Laurence Zitvogel 01/08/24 Cancer Cell
An IL-4 signalling axis in bone marrow drives pro-tumorigenic myelopoiesis Florent Ginhoux 01/04/24 Nature
Spectral Flow Cytometry Analysis of Resident Tissue Macrophages Wan Ting Kong, Mathilde Bied, Florent Ginhoux 01/01/24 Methods in molecular biology (Clifton, N.J.)
A screening system to determine the effect of bacterial metabolites on MAdCAM-1 expression by transformed endothelial sinusoidal cells Marine Fidelle, Laurence Zitvogel 01/01/24 Methods in Cell Biology
Robotic-assisted CT-guided percutaneous thermal ablation of abdominal tumors: An analysis of 41 patients Baptiste Bonnet, T. de Baere, Paul Beunon, Adlane Feddal, Lambros Tselikas, F. Deschamps 01/01/24 Diagnostic and interventional imaging
Residential proximity to vines and risk of childhood embryonal tumours in France - GEOCAP case-control study, 2006–2013 Véronique Minard-Colin 01/01/24 Environmental Research
Immunogenic cell death (ICD) enhancers—Drugs that enhance the perception of ICD by dendritic cells Laurence Zitvogel 01/01/24 Immunological Reviews
Deterministic reprogramming of neutrophils within tumors Camille Bleriot, Florent Ginhoux 01/01/24 Science
Sunitinib Treatment of VHL C162F Cells Slows Down Proliferation and Healing Ability via Downregulation of ZHX2 and Confers a Mesenchymal Phenotype Stéphanie Buart, Isabelle Damei, Salem Chouaib 01/01/24 Cancers
Circulating senescent myeloid cells infiltrate the brain and cause neurodegeneration in histiocytic disorders Camille Bigenwald, Aymeric Silvin, Florent Ginhoux 12/12/23 Immunity
Guidelines for mouse and human DC functional assays Charles Antoine Dutertre, Florent Ginhoux, Wan Ting Kong 12/01/23 European Journal of Immunology
Impact of the intestinal microbiota in colorectal cancer Marine Fidelle, Jianzhou Chen, Laurence Zitvogel 12/01/23 Bulletin de l'Academie Nationale de Medecine
Hypoxia as a potential inducer of immune tolerance, tumor plasticity and a driver of tumor mutational burden: Impact on cancer immunotherapy Sophie Gad 12/01/23 Seminars in Cancer Biology
A new generation of comprehensive precision oncology trials Birgit Geoerger 12/01/23 The Lancet Oncology

Number of publications of the laboratory by scientific field (2016-2021)

Every paper can be classified in one or more scientific fields. The figure below shows the lab's number of publications in each scientific field, according to the ASJC classification (Elsevier)