Hypertension pulmonaire : physiopathologie et innovation thérapeutique (HPPIT)

Laboratory presentation

Inserm UMR-S 999 is a major actor in national and international translational research on pulmonary hypertension, leading to major physiopathological, medical and surgical advances. It is subdivided into two research, physiopathological and clinical teams composed of researchers, clinicians and surgeons who have been working in synergy since 2010. Thanks to a national register of patients (National Reference Center for Severe Pulmonary Hypertension), a biobank of cells and tissues, and an internationally recognized expertise, the two teams are studying the mechanisms of pulmonary vascular remodeling and associated heart disease in humans, rodents and large animals.

The 19 latest publications

Title Authors Publication date Source
Treatment of sinus venosus defect: Time to tune Sebastien Hascoët, Clément Batteux 03/15/24 International Journal of Cardiology
Sarcoidosis-Associated Pulmonary Hypertension Laurent Savale, Athénaïs Boucly, Xavier Jaïs, Thomas Lacoste-Palasset, Mitja Jevnikar, Andrei Seferian, Marc Humbert, Olivier Sitbon, David Montani 03/01/24 Clinics in Chest Medicine
Assessing the role of phosphorylated S6 ribosomal protein in the pathological diagnosis of pulmonary antibody-mediated rejection Jérôme Le Pavec, Peter Dorfmuller 03/01/24 Journal of Heart and Lung Transplantation
Hepatopulmonary syndrome F. Robert, Laurent Savale 03/01/24 Revue de Medecine Interne
Doppler echocardiography for surveillance of acute cardiac allograft rejection: a 28-year single-center experience Julien Guihaire 02/15/24 Cardiovascular Diagnosis and Therapy
Effects of B Cell Depletion by CD19-Targeted Chimeric Antigen Receptor T Cells in a Murine Model of Systemic Sclerosis Ly Tu, Raphaël Thuillet, Mina Ottaviani, Christophe Guignabert 02/01/24 Arthritis and Rheumatology
High and intermediate risk pulmonary embolism in the ICU Laurent Savale 02/01/24 Intensive Care Medicine
Long-term outcomes after heart transplantation in adult patients with univentricular versus biventricular congenital heart disease Sebastien Hascoët 02/01/24 European Journal of Cardio-thoracic Surgery
Pulmonary veno-occlusive disease: illustrative cases and literature review Benoit Lechartier, Athénaïs Boucly, Sabina Solinas, Olivier Sitbon, David Montani 01/31/24 European Respiratory Review
Quest for a Lifelong Pulmonary Valve in Repaired Tetralogy of Fallot: Valve Bioengineering Is Needed Sebastien Hascoët 01/22/24 JACC: Cardiovascular Interventions
Transcatheter Pulmonary Valve Replacement: History Is on the Move Sebastien Hascoët 01/22/24 JACC: Cardiovascular Interventions
Outcomes of transcatheter pulmonary SAPIEN 3 valve implantation: an international registry Sebastien Hascoët, Estibaliz Valdeolmillos 01/14/24 European Heart Journal
Balanced solution versus saline in critically ill patients: a new piece to the puzzle! Xavier Monnet 01/01/24 Intensive Care Medicine
Vasoconstriction in septic shock Xavier Monnet 01/01/24 Intensive Care Medicine
Impact of heterozygous ALK1 mutations on the transcriptomic response to BMP9 and BMP10 in endothelial cells from hereditary hemorrhagic telangiectasia and pulmonary arterial hypertension donors L. Tu, Christophe Guignabert 01/01/24 Angiogenesis
4D flow cardiac MRI to assess pulmonary blood flow in patients with pulmonary arterial hypertension associated with congenital heart disease Estibaliz Valdeolmillos, Olivier Sitbon, David Montani, Xavier Jaïs, Laurent Savale, Marc Humbert, Arshid Azarine, Sebastien Hascoët 01/01/24 Diagnostic and interventional imaging
Central role of ubiquitin-specific protease 8 in leptin signaling pathway in pulmonary arterial hypertension Etienne Marie Jutant, Mustapha K. Chelgham, Mina Ottaviani, Raphaël Thuillet, Benjamin Le Vely, Marc Humbert, Christophe Guignabert, Ly Tu, Alice Huertas 01/01/24 Journal of Heart and Lung Transplantation
Thirty years of surgical management of pediatric pulmonary hypertension: Mid-term outcomes following reverse Potts shunt and transplantation Estibaliz Valdeolmillos, Jérôme Le Pavec, Marion Audié, Laurent Savale, Xavier Jaïs, David Montani, Olivier Sitbon, Séverine Feuillet, Olaf Mercier, Marc Humbert, Elie Fadel, Sebastien Hascoët 01/01/24 Journal of Thoracic and Cardiovascular Surgery
Pulmonary hypertension in connective tissue diseases: What every CTD specialist should know – but is afraid to ask! Laurent Savale, David Montani 01/01/24 Revue de Medecine Interne

Number of publications of the laboratory by scientific field (2016-2021)

Every paper can be classified in one or more scientific fields. The figure below shows the lab's number of publications in each scientific field, according to the ASJC classification (Elsevier)