Hémostase, inflammation, thrombose (HITh)

Laboratory presentation

The Hemostasis, Inflammation and Thrombosis Unit is interested in the platelets biology and associated cardiovascular diseases. This well-defined research perimeters, hospital involvement and the I2B's technical resources at the Bicêtre hospital site offer high international visibility. It brings together two synergistic teams, each made up of biologists and clinicians. Team 1 studies the physiology of haemostasis and its pathological aspects, focusing particularly on haemorrhagic pathologies, such as hemophilia, Willebrand disease, filaminopathies, gray platelet syndrome or Scott\'s syndrome. In addition, this team is in charge of the nanobodies synthesis, new tools created from antibodies for the study of biological phenomena and the treatment of pathologies. Team 2 is interested in the communication between inflammation and hemostasis and its implications in vascular pathologies as well as in platelet and endothelial calcium homeostasis. Some projects are of a fundamental nature while another aspect aims to develop new therapies.

The 20 latest publications

Title Authors Publication date Source
Comparison of the Alinity M STI with the GeneXpert CT/NG for the detection of sexually transmitted microorganisms Marc Vasse 03/01/24 Diagnostic Microbiology and Infectious Disease
The Bicêtre occlusion scale is well suited to assess the efficacy of the Contour embolization device J. Caroff 03/01/24 Journal of Neuroradiology
The effects of time and temperature on the in vitro stability of emicizumab in blood samples: Implications for laboratory and clinical practices Dominique Lasne, Delphine Borgel, Claire Auditeau 03/01/24 Haemophilia
Emicizumab and asparaginase, A first experience to share Delphine Borgel, Dominique Lasne 03/01/24 Haemophilia
Hemophilia A treatment innovation: factor VIII mimetic bispecific antibodies—generational enhancement Peter J. Lenting 02/01/24 Journal of Thrombosis and Haemostasis
Acquired haemophilia A in paediatric patients: A retrospective French cohort of eight cases Roseline d'Oiron 02/01/24 British Journal of Haematology
The Protein Kinase A Inhibitor KT5720 Prevents Endothelial Dysfunctions Induced by High-Dose Irradiation Régis Bobe 02/01/24 International Journal of Molecular Sciences
Sonorheometry Device Thresholds in Liver Transplantation: An Observational Retrospective Study Stéphanie Roullet 02/01/24 Journal of Clinical Medicine
Evaluation of the MTS™ aztreonam-avibactam strip (Liofilchem) on New Delhi metallo-β-lactamase-producing Enterobacterales Vasse Marc 01/01/24 European Journal of Clinical Microbiology and Infectious Diseases
Two-pore channels (TPCs) acts as a hub for excitation-contraction coupling, metabolism and cardiac hypertrophy signalling Antoine de Zélicourt, Abdallah Fayssoil, Mbarka Dakouane-Giudicelli, Sabine de la Porte 01/01/24 Cell Calcium
Mollicutes-related infections in thoracic surgery including lung and heart transplantation: A systematic review Marc Vasse 01/01/24 Journal of Heart and Lung Transplantation
Bleeding risks in preoperative plasmapheresis Tiffany Pascreau 01/01/24 Journal of Heart and Lung Transplantation
Letter to the editor regarding “Protein Z and Protein Z-dependent protease inhibitor in patients with acute ischemic stroke: A prospective mechanistic study” Tiffany Pascreau, Marc Vasse 01/01/24 Journal of Stroke and Cerebrovascular Diseases
Thrombin generation on vascular cells in the presence of factor VIII and/or emicizumab Sénadé Atsou, Peter J. Lenting, Cécile V. Denis, Olivier D. Christophe 01/01/24 Journal of Thrombosis and Haemostasis
Interest in the new thromboelastometry device, Clot Pro®, for predicting thrombocytopenia and hypofibrinogenemia during lung transplantation Tiffany Pascreau, Marc Vasse 01/01/24 Thrombosis Research
Deregulation of the p19/CDK4/CDK6 axis in Jak2<sup>V617F</sup> megakaryocytes accelerates the development of myelofibrosis Alexandre Kauskot 01/01/24 Leukemia
Plasmin-cleaved von Willebrand factor as a biomarker for microvascular thrombosis Peter J. Lenting 01/01/24 Blood
Thromboembolic Events With the Woven Endobridge Device: Incidence, Predictive Factors, and Management J. Caroff 01/01/24 Neurosurgery
Can Haematological Parameters Discriminate COVID-19 from Influenza? Tiffany Pascreau, Marc Vasse 01/01/24 Journal of Clinical Medicine
Toll-like receptor 4 and macrophage scavenger receptor 1 crosstalk regulates phagocytosis of a fungal pathogen Olivier D. Christophe 12/01/23 Nature Communications

Number of publications of the laboratory by scientific field (2016-2021)

Every paper can be classified in one or more scientific fields. The figure below shows the lab's number of publications in each scientific field, according to the ASJC classification (Elsevier)