Chimie et modélisation pour la biologie du cancer (CMBC)

Laboratory presentation

The central activity of the CMIB unit is to develop small molecules to investigate and control the biological activities of the main targets involved in cancer. These are essentially non-B (quadruplex) nucleic acid structures and kinases. IR-photoexcitable probes designed for both subcellular monitoring and targeted photo-aging are also important research axes. The drug and probe design activity is supported by the molecular modeling approach and Multimodal imaging (TEM, NanoSIMS, MRI). These approaches include the development of image processing and analysis methods as well as the design of software tools and protocols for biology imaging. The CMIB unit hosts the Institut Curie-CNRS library, 9000 chemical compounds, preclinical MRI imaging and chemical imaging platforms.

The 20 latest publications

Title Authors Publication date Source
Photophysical properties of 3-arylthioimidazo[1,2-a]pyridine derivatives: The role of peripheral electron-donating and electron-withdrawing groups in the advance of organic materials engineering Julie le Bescont, Chloé Breton-Patient 03/15/24 Journal of Molecular Structure
Visualization of an Endogenous Mitochondrial Azoreductase Activity under Normoxic Conditions Using a Naphthalimide Azo-Based Fluorogenic Probe Laurane Michel, Laurie Askenatzis, Marie Ange Badet-Denisot, Jerome Bignon, Philippe Durand, Arnaud Chevalier 01/30/24 Analytical Chemistry
A sodium/potassium switch for G4-prone G/C-rich sequences Yu Luo, Daniela Verga 01/11/24 Nucleic Acids Research
Temporal regulation of transgene expression controlled by amino acid availability in human T cells Pierre Verrelle 01/01/24 HLA
AGuIX nanoparticle-nanobody bioconjugates to target immune checkpoint receptors Charles Truillet 12/06/23 Nanoscale
Valkyrie Probes: A Novel Class of Enzyme-Activatable Photosensitizers based on Sulfur- and Seleno-Rosamines with Pyridinium Unit** Kévin Renault 11/16/23 Chemistry - An Asian Journal
Alternative splicing of BCL-x is controlled by RBM25 binding to a G-quadruplex in BCL-x pre-mRNA Oksana Reznichenko, Pedro Guixens-Gallardo, Marie Paule Teulade-Fichou, Anton Granzhan 11/10/23 Nucleic Acids Research
Unprecedented reactivity of polyamines with aldehydic DNA modifications: structural determinants of reactivity, characterization and enzymatic stability of adducts Eka Putra Gusti Ngurah Putu, Laurent Cattiaux, Sophie Bombard, Anton Granzhan 11/10/23 Nucleic Acids Research
Guidelines for G-quadruplexes: I. In vitro characterization Yu Luo, Anton Granzhan, Daniela Verga 11/01/23 Biochimie
The hide-and-seek game of the oncogenic Epstein-Barr virus-encoded EBNA1 protein with the immune system: An RNA G-quadruplex tale Anton Granzhan 11/01/23 Biochimie
Solution and Gas-Phase Stability of DNA Junctions from Temperature-Controlled Electrospray Ionization and Surface-Induced Dissociation Anton Granzhan 09/26/23 Analytical Chemistry
Ultrabright two-photon excitable red-emissive fluorogenic probes for fast and wash-free bioorthogonal labelling in live cells Marie Auvray, Delphine Naud-Martin, Gaëlle Fontaine, Florence Mahuteau-Betzer 07/04/23 Chemical Science
Visible-Light-Induced Insertion of Sulfur Dioxide Mediated by Electron Donor–Acceptor Complex: Synthesis and Photophysical Properties of 3-Sulfonyl Indolizines Delphine Naud-Martin, Marharyta Kosiuha, Florence Mahuteau-Betzer 06/06/23 European Journal of Organic Chemistry
3-arylthioimidazo[1,2-a]pyridine derivatives: A theoretical and experimental study of its photophysical properties Julie le Bescont, Chloé Breton-Patient 06/01/23 Journal of Photochemistry and Photobiology A: Chemistry
Anti-Cancer and Radio-Sensitizing Properties of New Bimetallic (N-Heterocyclic Carbene)-Amine-Pt(II) Complexes Tao Jia, Deepanjan Ghosh, Gaelle Fontaine, Ytabelle Maga Moulai Siasia, Sophie Bombard 05/25/23 Journal of Medicinal Chemistry
PSL Chemical Biology Symposia Third Edition: A Branch of Science in its Explosive Phase Daniela Verga 04/17/23 ChemBioChem
TRANSLACOL project: Nodal human papillomavirus tumoral DNA detection by ddPCR for survival prediction in early cervical cancer patients without pelvic lymph node invasion Pascal Rigolet 04/01/23 Journal of Clinical Virology
ASC-G4, an algorithm to calculate advanced structural characteristics of G-quadruplexes Marc Farag, Liliane Mouawad 03/21/23 Nucleic Acids Research
Two-photon absorption in imidazo[1,2-a]pyridine derivatives: Study of nonlinear optical response and dipolar properties Julie le Bescont, Chloé Breton-Patient 03/01/23 Journal of Molecular Liquids
How to Use Nested Probes Coupling to Increase the Local NMR/MRI Resolution and Sensitivity for Specific Experiments Mihaela Lupu, Joel Mispelter 02/01/23 Electronics (Switzerland)

Number of publications of the laboratory by scientific field (2016-2021)

Every paper can be classified in one or more scientific fields. The figure below shows the lab's number of publications in each scientific field, according to the ASJC classification (Elsevier)