Biomolécules : conception, isolement, synthèse (BioCIS)

Laboratory presentation

The CNRS BioCIS UMR (Biomolecules: Design, Isolation, Synthesis) is a major player in academic research within the Pharmacy UFR (Paris-Saclay University). It has solid expertise in the field of biologically active natural substances, the development of synthesis methodologies and the rational design of new chemical entities (NECs) for therapeutic purposes. Our research efforts in therapeutic innovation focus primarily on neurodegenerative diseases (eg, synucleinopathies, tauopathies) and rare diseases (PAH, epilepsies), anti-infectious, antiparasitic and anti-tumor agents (eg, immuno-oncology, immunoconjugates). The scientific objective is the search for bioactive NECs in the aforementioned fields. With the establishment of a screening platform (CIBLOT) and the possession of a chemical library (approximately 2000 molecules), the scientific expertise of BioCIS is recognized in the fields of natural and synthetic substances. Our partnership approach with biotechnology companies or national and international pharmaceutical groups on eminently topical research projects and our ability to develop our activity at the chemistry-biology interface (filing of patents) clearly illustrate the successes achieved by BioCIS in the field of therapeutic innovation.

The 20 latest publications

Title Authors Publication date Source
Synthesis and biological evaluation of selective Pepstatin based trifluoromethylated inhibitors of Cathepsin D Francesco Terzani, Sherazade Belhattab, Aurore Le Guern, Karine Guitot, Olivier Monasson, Chiara Zanato, Evelyne Chelain, Julien Pytkowicz 03/05/24 European Journal of Medicinal Chemistry
Developments in the chemistry and biology of 1,2,3-triazolyl-C-nucleosides Angélique Ferry, Florian Gallier, Nadège Lubin-Germain, Jacques Uziel, Simon Gonzales 03/01/24 Archiv der Pharmazie
Synthesis, Reactivity, and Antibacterial Activity of gem-Difluoroalkene, Difluoromethyl, and Trifluoromethyl β-Lactams Benoît Crousse 01/26/24 Organic Letters
3D printing of gellan-dextran methacrylate IPNs in glycerol and their bioadhesion by RGD derivatives Olivier Monasson, Elisa Peroni 01/01/24 Journal of Biomedical Materials Research - Part A
Structure-based molecular networking, molecular docking, dynamics simulation and pharmacokinetic studies of Olax subscorpioidea for identification of potential inhibitors against selected cancer targets Mehdi A. Beniddir 01/01/24 Journal of Biomolecular Structure and Dynamics
N-linked glycosylation of the M-protein variable region: glycoproteogenomics reveals a new layer of personalized complexity in multiple myeloma Simon Nadal 01/01/24 Clinical Chemistry and Laboratory Medicine
Electrochemical Nickel-Catalyzed Selective Inter- and Intramolecular Arylations of Cysteine-Containing Peptides** Olivier Monasson, Elisa Peroni 12/11/23 Angewandte Chemie - International Edition
Development and qualification of clinical grade decellularized and cryopreserved human esophagi Olivier Monasson, Elisa Peroni 12/01/23 Scientific Reports
Directed copper-catalyzed dehydrogenative C-H amination of unsaturated sialic acids Linlin Li, Angélique Ferry 11/27/23 Organic Chemistry Frontiers
Synthesis of new 3-acetyl-1,3,4-oxadiazolines combined with pyrimidines as antileishmanial and antiviral agents Indira Dennemont, Philippe M. Loiseau 10/01/23 Molecular Diversity
Introduction of constrained Trp analogs in RW9 modulates structure and partition in membrane models Camille Lozada, Simon Gonzalez, Luca Manciocchi, Liuba Mazzanti, Tâp Ha-Duong, Nadège Lubin-Germain 10/01/23 Bioorganic Chemistry
Difluoroalanine: Synthesis, Incorporation in Peptides, and Hydrophobic Contribution Assessment Yazid Boutahri, Khoubaib Ben Haj Salah, Nicolas Tisserand, Nathalie Lensen, Benoît Crousse, Thierry Brigaud 09/22/23 Organic Letters
Trifluoromethylthiolation of Tryptophan and Tyrosine Derivatives: A Tool for Enhancing the Local Hydrophobicity of Peptides Jure Gregorc, Nathalie Lensen, Grégory Chaume, Thierry Brigaud 09/15/23 Journal of Organic Chemistry
Recent Advances in the Syntheses of N-CF<inf>3</inf> Scaffolds up to Their Valorization Benoît Crousse 09/01/23 Chemical Record
Supramolecular assemblies from antimony(V) complexes for the treatment of leishmaniasis Sébastien Pomel, Philippe M. Loiseau 08/01/23 Biophysical Reviews
Benzodithiazoles-Sulfoximines: Preparation, Properties and Reactivities as Radical Perfluoroalkylating Agents Samir Messaoudi 07/18/23 Advanced Synthesis and Catalysis
Operationally simple enzymatic deprotection of C-3 position on 3,4,6-tri-O-acetyl-D-glucal Yuqing Zhang 07/01/23 Carbohydrate Research
Synthesis of novel partially perfluorinated C-glycosides and their application in blanching easel painting restoration Yuqing Zhang, Florian Gallier, Nadège Lubin-Germain 07/01/23 Journal of Cultural Heritage
Characterization of extensive 2-fluorodeschloroketamine metabolism in pooled human liver microsomes, urine and hair from an addicted patient using high-resolution accurate mass spectrometry Delphine Joseph 07/01/23 Journal of Analytical Toxicology
Mechanochemical Studies on Coupling of Hydrazines and Hydrazine Amides with Phenolic and Furanyl Aldehydes—Hydrazones with Antileishmanial and Antibacterial Activities Nicolas Imbert, Sandrine Cojean, Philippe M. Loiseau 07/01/23 Molecules

Number of publications of the laboratory by scientific field (2016-2021)

Every paper can be classified in one or more scientific fields. The figure below shows the lab's number of publications in each scientific field, according to the ASJC classification (Elsevier)