Signalisation et physiopathologie cardiovasculaire (CARPAT)

Présentation du laboratoire

Le SPC s'articule autour de trois équipes développant des thèmes complémentaires sur des modèles animaux et cellulaires pour étudier les mécanismes impliqués dans la fonction cardiaque au travers des récepteurs membranaires, des canaux ioniques, des nucléotides cycliques, du métabolisme énergétique, du calcium, et de compartiments intracellulaires.
L'unité a vocation à élucider des nouveaux mécanismes physiopathologiques et identifier de nouvelles cibles thérapeutiques dans les traitements de l'insuffisance cardiaque et des arythmies.Elle est en charge de projets novateurs au sein du LabEx LERMIT en partenariat avec les autres laboratoires de l'IPSIT.

Les 20 dernières publications

Titre Auteurs Date de publication Source
Contribution of transient receptor potential canonical channels in human and experimental pulmonary arterial hypertension Jessica Sabourin 01/08/2023 American Journal of Physiology - Lung Cellular and Molecular Physiology
Effects of Dichlorvos on cardiac cells: Toxicity and molecular mechanism of action Julie Pires Da Silva 01/07/2023 Chemosphere
Sexual dimorphism in acute myocardial infarction-induced acute kidney injury: cardiorenal deteriorating effects of ovariectomy in premenopausal female mice Nada J. Habeichi, Mathias Mericskay, Fouad A. Zouein 01/01/2023 Clinical Science
Development of a Thin-Layer Chromatography-Enzymatic Test Combination Method for the Isolation of α-Glucosidase Inhibitors from Thymelaea hirsuta Rodolphe Fishmeister, Veronique Leblais 01/01/2023 Journal of Chromatographic Science
Identification of Cx43 variants predisposing to ventricular fibrillation in the acute phase of ST-elevation myocardial infarction Rosa Doñate Puertas 01/01/2023 Europace
Machine learning-based scoring system to predict in-hospital outcomes in patients hospitalized with COVID-19 Delphine Mika 01/12/2022 Archives of Cardiovascular Diseases
Sex differences in cardiac remodeling post myocardial infarction with acute cigarette smoking Fouad A. Zouein 01/12/2022 Biology of Sex Differences
Impacts of a high-fat diet on the metabolic profile and the phenotype of atrial myocardium in mice Marie Lhomme, Mathias Mericskay 01/11/2022 Cardiovascular Research
Orai1 Inhibitors as Potential Treatments for Pulmonary Arterial Hypertension Jessica Sabourin, Jean Pierre Benitah 14/10/2022 Circulation Research
Housekeeping Proteins Exhibit a High Level of Expression Variability Within Control Group and Between Ischemic Human Heart Biopsies Anne Sophie Colombe, Pascale Gerbaud, Jean Pierre Benitah, Guillaume Pidoux 20/09/2022 Journal of the American Heart Association
Uptake-leak balance of SR Ca<sup>2+</sup> determines arrhythmogenic potential of RyR2<sup>R420Q+/−</sup> cardiomyocytes Pascale Gerbaud, Ana Maria Gomez 01/09/2022 Journal of Molecular and Cellular Cardiology
Genomic, Proteomic, and Metabolic Comparisons of Small Animal Models of Heart Failure With Preserved Ejection Fraction: A Tale of Mice, Rats, and Cats Nada J. Habeichi, Fouad A. Zouein 02/08/2022 Journal of the American Heart Association
Triazole fungicide tebuconazole induces apoptosis through ROS-mediated endoplasmic reticulum stress pathway Kevin Monceaux, Anissa Belhadef, Ahmed Karoui, Christophe Lemaire 01/08/2022 Environmental Toxicology and Pharmacology
Interrelation between α-Cardiac Actin Treadmilling and Myocardin-Related Transcription Factor-A Nuclear Shuttling in Cardiomyocytes Mathias Mericskay 01/07/2022 International Journal of Molecular Sciences
Commentary on structures of the junctophilin/voltage-gated calcium channel interface reveal hot spot for cardiomyopathy mutations Jean Pierre Benitah, Ana Maria Gomez 01/06/2022 Cell Calcium
Ferulic Acid, Pterostilbene, and Tyrosol Protect the Heart from ER-Stress-Induced Injury by Activating SIRT1-Dependent Deacetylation of eIF2α Kevin Monceaux, Mélanie Gressette, Ahmed Karoui, Julie Pires Da Silva, Jérome Piquereau, Renée Ventura-Clapier, Anne Garnier, Mathias Mericskay, Christophe Lemaire 01/06/2022 International Journal of Molecular Sciences
CD38-NADase is a new major contributor to Duchenne muscular dystrophic phenotype Ahmed Karoui, Florence Lefebvre, Jérome Piquereau, Mathias Mericskay, Ana Maria Gomez 09/05/2022 EMBO Molecular Medicine
Cyclic GMP modulating drugs in cardiovascular diseases: mechanism-based network pharmacology Rodolphe Fischmeister 01/05/2022 Cardiovascular Research
Phosphodiesterase type 4 anchoring regulates cAMP signaling to Popeye domain-containing proteins Delphine Mika, Grégoire Vandecasteele 01/04/2022 Journal of Molecular and Cellular Cardiology
Prognostic value of right ventricular dilatation in patients with COVID-19: a multicentre study Delphine Mika 01/04/2022 European Heart Journal Cardiovascular Imaging

Nombre de publications du laboratoire par domaine scientifique (2016-2021)

Chaque publication du laboratoire peut être rangée dans une ou plusieurs disciplines scientifiques : la figure ci-dessus présente le nombre de publications du laboratoire pour chaque discipline de la classification ASJC (Elsevier)